Diamine Oxidase Activity Blood Test Marylebone
From 1 October 2026 — until then book at South Kensington or St Paul's. South Kensington · St Paul's
£113
+ £50 phlebotomy fee (per visit)
+ £50 phlebotomy (per visit)
Confidential Results
Secure online portal
Fast Results
2 weeks"
Professional Service
Experienced phlebotomists
Wimpole Street, Marylebone (opening 1 October 2026)
Opening hours from 1 October 2026
- Monday
- 9am – 6pm
- Tuesday
- 9am – 8pm
- Wednesday
- 9am – 6pm
- Thursday
- 9am – 8pm
- Friday
- 8am – 5pm
- Saturday
- 10am – 4pm
- Sunday
- Closed
- Bond Street — about 6 minutes (Central, Jubilee & Elizabeth lines)
- Oxford Circus — about 7 minutes (Central, Bakerloo & Victoria lines)
Wimpole Street, Marylebone
Diamine Oxidase Activity is a food intolerance and digestive sensitivity test concerned with histamine intolerance, enzyme activity and digestive system, run on a venous blood sample (serum). At Wimpole Street it is priced at £113 for everyone and, from 1 October 2026, a nurse or phlebotomist takes the sample at 22 Wimpole Street, Marylebone. The laboratory quotes 2 weeks; the report, with reference ranges, is delivered to your secure portal for you to discuss with your GP or a clinician.
Diamine Oxidase Activity’s place in food intolerance and digestive sensitivity testing
- Sample
- venous blood sample (serum)
- Laboratory turnaround
- 2 weeks
- Appointment
- 20 minutes
- Standard price
- £113 + £50 phlebotomy per visit
Who considers Diamine Oxidase Activity
- People often consider these tests if they get bloating, cramps or loose stools an hour or two after milk, cheese or ice cream.
- Flushing, headaches, nasal congestion or hives after red wine, aged cheese or cured meats sometimes lead to a DAO or histamine test.
- Those who feel better off gluten but have tested negative for coeliac disease may want a fuller evaluation.
- Anyone about to embark on a restrictive elimination diet may prefer to gather objective information first.
- Long-standing irritable bowel symptoms without a clear pattern are a frequent reason to explore intolerance.
What Diamine Oxidase Activity measures
Laboratories file the Diamine Oxidase Activity under histamine intolerance, enzyme activity and digestive system. The following sections set out how a food intolerance and digestive sensitivity test of this kind is measured and read.
Food intolerance tests in the catalogue measure mechanisms other than IgE allergy: the lactose intolerance gene test identifies the common variant that switches lactase off in adulthood, diamine oxidase (DAO) activity estimates how well histamine from food is broken down, and histamine itself can be measured in urine. Gluten sensitivity evaluations combine coeliac serology with related nutritional markers for people whose symptoms do not fit classic coeliac disease. These tests address digestive and metabolic reactions rather than immune allergy.
Preparing for your Diamine Oxidase Activity
- 1No fasting is needed for the lactose gene test; it is not affected by diet.
- 2For DAO activity, avoid alcohol and antihistamines for 24 hours, and note any DAO supplements you take.
- 3Keep eating gluten for six weeks if coeliac serology forms part of the profile.
Sample for this test: venous blood sample (serum).
Understanding your Diamine Oxidase Activity results
Carrying the lactase non-persistence genotype can indicate a predisposition to lactose intolerance, though many carriers tolerate moderate amounts of dairy and the result is not a measure of current symptoms. A low DAO activity may suggest reduced capacity to clear dietary histamine, which is one possible contributor to food-related symptoms but not a validated diagnosis on its own. Gluten sensitivity profiles are interpreted mainly to exclude coeliac disease and nutritional deficiency; there is no blood test that confirms non-coeliac gluten sensitivity.
Intolerance tests provide supporting information for a structured dietary approach and are not a substitute for supervised elimination and reintroduction with a dietitian.
Related areas of testing at Wimpole Street: coeliac disease and gluten, allergy — specific IgE, stool tests, nutrition, vitamins and trace elements.
Pricing
Diamine Oxidase Activity
Individual test
Phlebotomy Fee
Blood draw by qualified phlebotomist (per visit)
Total
£163Payment is collected at the clinic. The phlebotomy fee is charged once per visit, regardless of the number of tests booked.
From booking the Diamine Oxidase Activity to reading your result
- 1
Choose your test
Select the Diamine Oxidase Activity and any others you want run from the same visit. Until 1 October 2026 the identical test can be booked at South Kensington or St Paul’s.
- 2
Nurse-led sample
From 1 October 2026 the venous blood sample (serum) is taken at 22 Wimpole Street, Marylebone by our nursing team, led by Precious Agbonmamwen, Registered Adult Nurse (NMC 20H1641E). Identity is checked and any preparation questions answered first.
- 3
UKAS-accredited laboratory
The sample travels to a UKAS-accredited partner laboratory, whose methods and reference ranges match those used across the NHS and private sectors.
- 4
Laboratory report to your secure portal
The laboratory report is released to your secure portal — typically from 24 hours; the laboratory quotes 2 weeks for this test. It shows each value against the reference range and flags anything outside it; discuss the report with your GP or a clinician.
Why test at Wimpole Street
Wimpole Street Medical & Dental opens at 22 Wimpole Street on 1 October 2026. Medical services are for patients aged 16 and over; registration with the CQC is in progress ahead of opening.
Wimpole Street, Marylebone (opening 1 October 2026)
- Bond Street — about 6 minutes (Central, Jubilee & Elizabeth lines)
- Oxford Circus — about 7 minutes (Central, Bakerloo & Victoria lines)
- Registration with the CQC is in progress ahead of opening; our South Kensington and St Paul’s clinics are CQC registered.
- One standard price applies to everyone — there is no members’ tier at Wimpole Street.
- Repeat or additional tests can usually be added to the same visit rather than requiring a second appointment.
Other tests often considered alongside Diamine Oxidase Activity
Frequently Asked Questions
A venous blood sample (serum). A nurse or phlebotomist collects it at 22 Wimpole Street, Marylebone from 1 October 2026; the appointment allows time for identity checks and any preparation questions. The laboratory quotes 2 weeks for this test.
Ready to Book Your Test?
Wimpole Street opens 1 October 2026. Register your interest for the Marylebone diary, or book the same test now at South Kensington or St Paul's.
Important information about the Diamine Oxidase Activity at Wimpole Street
- Medical services at Wimpole Street Medical & Dental are for patients aged 16 and over.
- This is a self-referral service: you choose the test and book directly — no GP referral is needed.
- Nurse-led by Precious Agbonmamwen, Registered Adult Nurse (NMC 20H1641E), who oversees sample-taking standards, infection control and the patient pathway. The nursing team does not interpret results.
- A laboratory result is not a diagnosis and this page is not a substitute for medical advice. We do not provide clinical interpretation of results — please discuss your report with your GP or a clinician, particularly if a value is flagged or you have symptoms.
- CQC registration for Wimpole Street is in progress ahead of the opening on 1 October 2026; our South Kensington and St Paul’s clinics are CQC registered.
- Your results are held on a secure portal and treated as strictly confidential, except where disclosure is required by law.
- If you are seriously unwell, call 999. For urgent advice that is not an emergency, call NHS 111.
