First Trimester Maternal Screen (PAPP-A/Free Beta-hCG) Blood Test Marylebone
From 1 October 2026 — until then book at South Kensington or St Paul's. South Kensington · St Paul's
£104
+ £50 phlebotomy fee (per visit)
+ £50 phlebotomy (per visit)
Confidential Results
Secure online portal
Fast Results
1 day"
Professional Service
Experienced phlebotomists
Wimpole Street, Marylebone (opening 1 October 2026)
Opening hours from 1 October 2026
- Monday
- 9am – 6pm
- Tuesday
- 9am – 8pm
- Wednesday
- 9am – 6pm
- Thursday
- 9am – 8pm
- Friday
- 8am – 5pm
- Saturday
- 10am – 4pm
- Sunday
- Closed
- Bond Street — about 6 minutes (Central, Jubilee & Elizabeth lines)
- Oxford Circus — about 7 minutes (Central, Bakerloo & Victoria lines)
Wimpole Street, Marylebone
First Trimester Maternal Screen (PAPP-A/Free Beta-hCG) is a pregnancy-related tests test concerned with pregnancy hormones, early pregnancy test and placenta, run on a venous blood sample (serum). At Wimpole Street it is priced at £104 for everyone and, from 1 October 2026, a nurse or phlebotomist takes the sample at 22 Wimpole Street, Marylebone. The laboratory quotes 1 day; the report, with reference ranges, is delivered to your secure portal for you to discuss with your GP or a clinician.
First Trimester Maternal Screen (PAPP-A/Free Beta-hCG)’s place in pregnancy-related tests testing
- Sample
- venous blood sample (serum)
- Laboratory turnaround
- 1 day
- Appointment
- 20 minutes
- Standard price
- £104 + £50 phlebotomy per visit
Preparing for your First Trimester Maternal Screen (PAPP-A/Free Beta-hCG)
- 1No fasting is needed for hCG, antenatal serology or NIPT.
- 2For NIPT, gestation should be at least 10 weeks; bring your dating scan details if you have them, as the request form needs the gestational age.
- 3If you are tracking hCG, keep the two samples about 48 hours apart and at a similar time of day.
- 4Tell the nurse about any bleeding, pain or previous ectopic pregnancy so the request can be prioritised appropriately.
Sample for this test: venous blood sample (serum).
What First Trimester Maternal Screen (PAPP-A/Free Beta-hCG) measures
First Trimester Maternal Screen (PAPP-A/Free Beta-hCG) is most often requested in connection with pregnancy hormones, early pregnancy test, placenta, human chorionic gonadotropin, pregnancy-associated plasma protein-A and baby's health, which is why it sits within the pregnancy-related tests group at Wimpole Street.
Pregnancy-related tests include quantitative hCG, which measures the pregnancy hormone in blood and can be tracked over 48 hours in early pregnancy; the antenatal profile of blood group, antibody screen, full blood count and infection serology; and TORCH screening for infections that matter in pregnancy. Non-invasive prenatal testing (NIPT) analyses fragments of placental DNA in maternal blood to screen for common chromosome differences, while first-trimester markers such as PAPP-A and free beta-hCG contribute to combined screening. Recurrent miscarriage and thrombotic risk profiles look for clotting and immune factors.
Who considers First Trimester Maternal Screen (PAPP-A/Free Beta-hCG)
- People often consider these tests if they want a blood confirmation of pregnancy earlier or more precisely than a urine stick allows.
- Those who have had two or more miscarriages frequently ask for a recurrent-loss panel before trying again.
- Anyone wanting private NIPT from 10 weeks alongside their NHS care is a common request.
- Women unsure of their rubella, varicella or hepatitis status may check immunity before or during pregnancy.
- A rhesus-negative blood group, or a previous transfusion, sometimes prompts an antibody screen.
Understanding your First Trimester Maternal Screen (PAPP-A/Free Beta-hCG) results
A rising hCG that roughly doubles over 48 hours in early pregnancy is typically reassuring, while a slow rise or fall can indicate a pregnancy that is not progressing normally and needs clinical assessment. NIPT reports a low- or high-probability result for each chromosome tested; a high-probability result is a screening finding, not a diagnosis, and is confirmed by diagnostic testing arranged through maternity services. Antibody screens and infection serology guide antenatal care rather than giving stand-alone answers.
Pregnancy blood tests complement, and do not replace, NHS antenatal care; results should be shared with your midwife or obstetric team.
Heavy bleeding, severe one-sided abdominal pain, shoulder-tip pain or fainting in early pregnancy needs urgent assessment — call 999 or go to your nearest emergency department or early pregnancy unit rather than waiting for a blood result.
Related areas of testing at Wimpole Street: female hormones and fertility, clotting and specialist haematology, genetic testing, viral infections and immunity.
Pricing
First Trimester Maternal Screen (PAPP-A/Free Beta-hCG)
Individual test
Phlebotomy Fee
Blood draw by qualified phlebotomist (per visit)
Total
£154Payment is collected at the clinic. The phlebotomy fee is charged once per visit, regardless of the number of tests booked.
From booking the First Trimester Maternal Screen (PAPP-A/Free Beta-hCG) to reading your result
- 1
Choose your test
Select the First Trimester Maternal Screen (PAPP-A/Free Beta-hCG) and any others you want run from the same visit. Until 1 October 2026 the identical test can be booked at South Kensington or St Paul’s.
- 2
Nurse-led sample
From 1 October 2026 the venous blood sample (serum) is taken at 22 Wimpole Street, Marylebone by our nursing team, led by Precious Agbonmamwen, Registered Adult Nurse (NMC 20H1641E). Identity is checked and any preparation questions answered first.
- 3
UKAS-accredited laboratory
The sample travels to a UKAS-accredited partner laboratory, whose methods and reference ranges match those used across the NHS and private sectors.
- 4
Laboratory report to your secure portal
The laboratory report is released to your secure portal — typically from 24 hours; the laboratory quotes 1 day for this test. It shows each value against the reference range and flags anything outside it; discuss the report with your GP or a clinician.
Why test at Wimpole Street
Wimpole Street Medical & Dental opens at 22 Wimpole Street on 1 October 2026. Medical services are for patients aged 16 and over; registration with the CQC is in progress ahead of opening.
Wimpole Street, Marylebone (opening 1 October 2026)
- Bond Street — about 6 minutes (Central, Jubilee & Elizabeth lines)
- Oxford Circus — about 7 minutes (Central, Bakerloo & Victoria lines)
- The same catalogue already runs at South Kensington and St Paul’s, so you can test now and move your records to Marylebone later.
- Repeat or additional tests can usually be added to the same visit rather than requiring a second appointment.
- Analysis is carried out by a UKAS-accredited partner laboratory, so methods and reference ranges match those used across the NHS.
Other tests often considered alongside First Trimester Maternal Screen (PAPP-A/Free Beta-hCG)
- Oestriol (Estriol)Wimpole Street, Marylebone · from 1 October 2026
- Non-Invasive Prenatal Testing (NIPT) – common aneuploidy screening from maternal bloodWimpole Street, Marylebone · from 1 October 2026
- Miscarriage/Thrombotic Risk ProfileWimpole Street, Marylebone · from 1 October 2026
- Inhibin AWimpole Street, Marylebone · from 1 October 2026
- HCG (Quantitative) (Venous)Wimpole Street, Marylebone · from 1 October 2026
Frequently Asked Questions
A venous blood sample (serum). A nurse or phlebotomist collects it at 22 Wimpole Street, Marylebone from 1 October 2026; the appointment allows time for identity checks and any preparation questions. The laboratory quotes 1 day for this test.
Ready to Book Your Test?
Wimpole Street opens 1 October 2026. Register your interest for the Marylebone diary, or book the same test now at South Kensington or St Paul's.
Important information about the First Trimester Maternal Screen (PAPP-A/Free Beta-hCG) at Wimpole Street
- Medical services at Wimpole Street Medical & Dental are for patients aged 16 and over.
- This is a self-referral service: you choose the test and book directly — no GP referral is needed.
- Nurse-led by Precious Agbonmamwen, Registered Adult Nurse (NMC 20H1641E), who oversees sample-taking standards, infection control and the patient pathway. The nursing team does not interpret results.
- A laboratory result is not a diagnosis and this page is not a substitute for medical advice. We do not provide clinical interpretation of results — please discuss your report with your GP or a clinician, particularly if a value is flagged or you have symptoms.
- CQC registration for Wimpole Street is in progress ahead of the opening on 1 October 2026; our South Kensington and St Paul’s clinics are CQC registered.
- Your results are held on a secure portal and treated as strictly confidential, except where disclosure is required by law.
- If you are seriously unwell, call 999. For urgent advice that is not an emergency, call NHS 111.
