Rheumatology Profile 2 (Connective tissue) Blood Test Marylebone
From 1 October 2026 — until then book at South Kensington or St Paul's. South Kensington · St Paul's
£487
+ £50 phlebotomy fee (per visit)
+ £50 phlebotomy (per visit)
Confidential Results
Secure online portal
Fast Results
3 days"
Professional Service
Experienced phlebotomists
Wimpole Street, Marylebone (opening 1 October 2026)
Opening hours from 1 October 2026
- Monday
- 9am – 6pm
- Tuesday
- 9am – 8pm
- Wednesday
- 9am – 6pm
- Thursday
- 9am – 8pm
- Friday
- 8am – 5pm
- Saturday
- 10am – 4pm
- Sunday
- Closed
- Bond Street — about 6 minutes (Central, Jubilee & Elizabeth lines)
- Oxford Circus — about 7 minutes (Central, Bakerloo & Victoria lines)
Wimpole Street, Marylebone
People looking into autoimmune disorders and joint inflammation in Marylebone are usually looking for the Rheumatology Profile 2 (Connective tissue). It belongs to our autoimmune and immunology group and needs a venous blood sample (serum and EDTA), which a nurse or phlebotomist collects at 22 Wimpole Street, Marylebone once the clinic opens on 1 October 2026. The laboratory typically returns a result in 3 days, and the standard price is £487 with no members’ tier.
Rheumatology Profile 2 (Connective tissue)’s place in autoimmune and immunology testing
- Sample
- venous blood sample (serum and EDTA)
- Laboratory turnaround
- 3 days
- Appointment
- 20 minutes
- Standard price
- £487 + £50 phlebotomy per visit
What Rheumatology Profile 2 (Connective tissue) measures
Rheumatology Profile 2 (Connective tissue) is most often requested in connection with autoimmune disorders, joint inflammation, lupus, rheumatoid Arthritis, scleroderma and connective tissue diseases, which is why it sits within the autoimmune and immunology group at Wimpole Street.
Autoimmune tests look for antibodies the immune system has produced against the body’s own tissues — anti-nuclear antibodies and ENA in connective tissue disease, rheumatoid factor and anti-CCP in rheumatoid arthritis, ANCA in vasculitis, and organ-specific antibodies for liver, muscle, nerve, skin and other targets. Immunology tests in the same group measure the components of the immune system itself: immunoglobulins and their subclasses, complement proteins, lymphocyte subsets and cytokines. Rheumatology profiles bundle the most commonly requested markers with inflammation tests.
Preparing for your Rheumatology Profile 2 (Connective tissue)
- 1No fasting is required for antibody or immunoglobulin tests.
- 2Steroids and immunosuppressant medicines can lower antibody levels; mention them so results are read in context.
- 3Try to test when symptoms are present rather than during a quiet spell, as some antibodies fluctuate with disease activity.
Sample for this test: venous blood sample (serum and EDTA).
Who considers Rheumatology Profile 2 (Connective tissue)
- People often consider autoimmune testing if they have joint pain and swelling in several joints, especially with morning stiffness lasting over an hour.
- A rash triggered by sunlight, mouth ulcers, dry eyes and mouth or Raynaud’s phenomenon are common prompts.
- Unexplained fatigue with abnormal liver or kidney tests may lead to organ-specific antibodies being checked.
- Muscle weakness, double vision or unusual nerve symptoms sometimes warrant neurological antibody panels.
- Recurrent infections can be a reason to measure immunoglobulins and lymphocyte subsets.
Understanding your Rheumatology Profile 2 (Connective tissue) results
A positive antibody can indicate an autoimmune tendency, but low-titre ANA in particular is found in a proportion of healthy people and rises with age, so pattern, titre and symptoms all matter. Specific antibodies such as anti-CCP, anti-dsDNA or ANCA carry more weight but still require clinical correlation. Low immunoglobulins or complement can indicate an immune deficiency or consumption during active disease and generally lead to specialist review.
Autoantibody results are supportive evidence, not a diagnosis; classification of any autoimmune condition depends on clinical criteria assessed by a specialist.
Related areas of testing at Wimpole Street: inflammation markers, coeliac disease and gluten, thyroid function, full blood count.
Pricing
Rheumatology Profile 2 (Connective tissue)
Individual test
Phlebotomy Fee
Blood draw by qualified phlebotomist (per visit)
Total
£537Payment is collected at the clinic. The phlebotomy fee is charged once per visit, regardless of the number of tests booked.
From booking the Rheumatology Profile 2 (Connective tissue) to reading your result
- 1
Choose your test
Select the Rheumatology Profile 2 (Connective tissue) and any others you want run from the same visit. Until 1 October 2026 the identical test can be booked at South Kensington or St Paul’s.
- 2
Nurse-led sample
From 1 October 2026 the venous blood sample (serum and EDTA) is taken at 22 Wimpole Street, Marylebone by our nursing team, led by Precious Agbonmamwen, Registered Adult Nurse (NMC 20H1641E). Identity is checked and any preparation questions answered first.
- 3
UKAS-accredited laboratory
The sample travels to a UKAS-accredited partner laboratory, whose methods and reference ranges match those used across the NHS and private sectors.
- 4
Laboratory report to your secure portal
The laboratory report is released to your secure portal — typically from 24 hours; the laboratory quotes 3 days for this test. It shows each value against the reference range and flags anything outside it; discuss the report with your GP or a clinician.
Why test at Wimpole Street
Wimpole Street Medical & Dental opens at 22 Wimpole Street on 1 October 2026. Medical services are for patients aged 16 and over; registration with the CQC is in progress ahead of opening.
Wimpole Street, Marylebone (opening 1 October 2026)
- Bond Street — about 6 minutes (Central, Jubilee & Elizabeth lines)
- Oxford Circus — about 7 minutes (Central, Bakerloo & Victoria lines)
- Analysis is carried out by a UKAS-accredited partner laboratory, so methods and reference ranges match those used across the NHS.
- Self-referral: you choose the test and book directly — no GP referral is needed, and the laboratory report is yours to take to your GP or a clinician.
- One standard price applies to everyone — there is no members’ tier at Wimpole Street.
Other tests often considered alongside Rheumatology Profile 2 (Connective tissue)
- Skin (Pemphigus/Pemphigoid) AutoantibodiesWimpole Street, Marylebone · from 1 October 2026
- Skin Antibodies by ImmunofluorescenceWimpole Street, Marylebone · from 1 October 2026
- Smooth Muscle AntibodiesWimpole Street, Marylebone · from 1 October 2026
- Striated/Skeletal Muscle AntibodyWimpole Street, Marylebone · from 1 October 2026
- T Regulatory CellsWimpole Street, Marylebone · from 1 October 2026
- Total Immune Function EvaluationWimpole Street, Marylebone · from 1 October 2026
Frequently Asked Questions
A venous blood sample (serum and EDTA). A nurse or phlebotomist collects it at 22 Wimpole Street, Marylebone from 1 October 2026; the appointment allows time for identity checks and any preparation questions. The laboratory quotes 3 days for this test.
Ready to Book Your Test?
Wimpole Street opens 1 October 2026. Register your interest for the Marylebone diary, or book the same test now at South Kensington or St Paul's.
Important information about the Rheumatology Profile 2 (Connective tissue) at Wimpole Street
- Medical services at Wimpole Street Medical & Dental are for patients aged 16 and over.
- This is a self-referral service: you choose the test and book directly — no GP referral is needed.
- Nurse-led by Precious Agbonmamwen, Registered Adult Nurse (NMC 20H1641E), who oversees sample-taking standards, infection control and the patient pathway. The nursing team does not interpret results.
- A laboratory result is not a diagnosis and this page is not a substitute for medical advice. We do not provide clinical interpretation of results — please discuss your report with your GP or a clinician, particularly if a value is flagged or you have symptoms.
- CQC registration for Wimpole Street is in progress ahead of the opening on 1 October 2026; our South Kensington and St Paul’s clinics are CQC registered.
- Your results are held on a secure portal and treated as strictly confidential, except where disclosure is required by law.
- If you are seriously unwell, call 999. For urgent advice that is not an emergency, call NHS 111.
